This book guides medicinal chemists in how to implement early ADMET testing in their workflow in order to improve both the speed and efficiency of their efforts. Although many pharmaceutical companies have dedicated groups directly interfacing with drug discovery, the scientific principles and strategies are practiced in a variety of different ways. This book answers the need to regularize the drug discovery interface; it defines and reviews the field of ADME for medicinal chemists. In addition, the scientific principles and the tools utilized by ADME scientists in a discovery setting, as applied to medicinal chemistry and structure modification to improve drug-like properties of drug candidates, are examined.
LEAVE IT TO CHANCE. Eleanor "Elle" Chance, that is-the intrepid heroine of this edgy new series that transforms elements of urban fantasy, historical adventure, and paranormal romance into pure storytelling gold.
In this monumental work, Raphael Patai opens up an entirely new field of cultural history by tracing Jewish alchemy from antiquity to the nineteenth century. Until now there has been little attention given to the significant role that Jews played in the field of alchemy. Here, drawing on an enormous range of previously unexplored sources, Patai reveals that Jews were major players in what was for centuries one of humanity's most compelling intellectual obsessions.
Originally published in 1994.
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