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It is often implied that antipsychotic-induced extrapyramidal side-effects are irrelevant to modern psychiatric therapeutics, rendered historic by newer, better treatments. This myth arises from limited awareness of the depth and breadth of neurological disruption antipsychotics can mediate. This volume discusses the extensive clinical boundaries of acute dystonias, drug-induced parkinsonism, akathisia and tardive dyskinesia, providing demographic and epidemiological context while illustrating how prescribing choices impact powerfully on their development. This new edition has been thoroughly updated and rewritten to include recent data, expanded references and a new chapter on the concept of 'atypical' antipsychotics. Written in a light, engaging style, liberally illustrated with clinical examples, it also invites readers to consider ongoing controversies - subjective drug effects, the relationship between 'akathisia' and restless legs, the status of the concept of 'atypicality', and so on. Informative reading for trainees as well as established practitioners in the fields of psychiatry, neurology, primary care and geriatrics.
The NATO Advanced Studies Institute series "Targeting of Drugs" was originated in 1981. It is now a major international forum, held every two years in Cape Sounion, Greece, in which the present and the future of this important area of research in drug delivery is discussed in great depth. Previous ASIs of the series dealt with drug carriers of natural and synthetic origin, their interaction with the biological milieu, ways by which the latter influences such interaction, strategies by which milieu interference curtailing the function of drug carriers is circumvented and, more recently, with the application of drug carriers for the delivery of peptides and proteins. The present book contains the of the 7th NATO ASI "Targeting of Drugs: Advances in System Constructs", proceedings held in Cape Sounion during 24 June -5 July 1993. As the title implies, the book deals with a variety of approaches to carrier design or modification that contribute to optimal carrier function. to Mrs Concha Perring for her assistance with the We express our appreciation organization of the ASI. We thank Dr. G. Deliconstantinos who, as chairperson of the Local Committee, contributed to the success of the Institute. The ASI was held under the sponsorship of NATO Scientific Affairs Division and co-sponsored and generously financed by SmithKline Beecham Pharmaceuticals (King of Prussia). Financial assistance was also provided by Liposome Technology Inc. (Menlo Park), Vestar Inc. (San Dimas) and Zeneka (Macclesfield).
If you work with children, you must have this book. For more than two decades, Pediatric Injectable Drugs (The Teddy Bear Book), has served an important and continuing need for reliable evidence-based information specific to pediatric injectable drugs. The tenth edition of this invaluable reference has grown to cover 238 drugs commonly used in the treatment of infants and children, including 20 new to this edition. The Teddy Bear Book covers neonates through adolescents, with age-specific dosing and administration guidelines throughout. With three new editors, who collectively bring 75 years of pediatric pharmacy practice experience to the book, the tenth edition is the most thorough and comprehensive reference yet. As with previous editions, the structure of each of the drug monographs covers the following areas:* Brand Names* Medication Error Potential* Contraindications and Warnings* Infusion-Related Cautions* Dosage (age specific)* Dosage Adjustment in Organ Dysfunction* Maximum Dosage* Additives* Suitable Diluents* Maximum Concentrations* Preparation and Delivery* IV Push* Intermittent Infusion* Continuous Infusion* Other Routes of Administration* Comments Also included is a comprehensive list of abbreviations and more than 4800 references. This is the only pediatric (neonates through adolescents) parenteral drug reference that covers limited fluid amounts, maximum doses, and limited intravenous sites - issues that pediatric practitioners often face in their patients. When it comes to pediatric injectable drugs, valid safety and efficacy research can be hard to locate. This indispensable reference changes all that.
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