<b>A comprehensive resource on case studies of marketed kinase drugs and promising drug trials</b> <p> Since the discovery of protein kinase activity in 1954, the field of protein kinase drug discovery has advanced dramatically. With the ongoing clinical success of the Bcr-Abl kinase inhibitor Gleevec in the treatment of chronic myelogenous leukemia and seven additional marketed kinase inhibitor drugs, researchers have compelling evidence that kinase inhibitors can be highly efficacious in the treatment of diseases caused by aberrant activity of protein kinase. Currently more than 100 protein kinase inhibitors are in clinical development. <p> In one comprehensive volume, the editors, Dr. Rongshi Li and Dr. Jeffrey Stafford, present timely and important case studies of marketed kinase drugs and several of the most advanced kinase inhibitors in clinical trials. <i>Kinase Inhibitor Drugs</i> includes: <ul> <li> <p> Case studies from leading investigators and experts in the field that provide firsthand accounts of kinase inhibitor discovery <li> <p> Current thinking on kinase structure, biochemistry, and signal transduction pathways <li> <p> Information on state-of-the-art technologies and tools such as structure-based and fragment-based drug discovery <li> <p> A lineup of clinical-phase growth factor receptor inhibitors <li> <p> Inhibitors of cell cycle kinases <li> <p> The discovery of allosteric inhibitors of MEK kinase <li> <p> Information on pharmacogenomics and its application to kinase inhibitor clinical development </ul>
This comprehensive reference guide describes more than 130 alphabetically arranged drugs of abuse, including both pharmaceutical and natural products. The book begins with a discussion of federal drug scheduling and drug categories. Individual entries for particular substances of abuse follow. Drug descriptions include: correct pronunciation, nicknames or street names, legal status, historical and present uses and misuses, abuse factors, interactions with other drugs, and findings of cancer risks and birth defects. Scientific information is presented in a clear, simple manner designed for students and general readers alike. In addition to the A-Z descriptions, Miller provides an explanation of general drug types, such as stimulants and hallucinogens, as well as the aspects of drug abuse, including tolerance and withdrawal. A list of print and electronic sources is also included for readers seeking further information.
Sex, Drugs and Rock n Roll - Teens tell it all, some lost it all while others finally found it, through God. See what God says about sex before marriage and other controversial subjects as you read from these true stories. Scripture is placed appropriately so anyone going through a similar situation will find truth and guidance. Includes information on various street drugs, their definitions, their street names; and the effects these drugs have on the user. A powerful section with specific word prayers for almost anything you or your teen could be going through to apply and gain victory!
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