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This volume comprises papers presented at the 40th Erice Course "From Molecules to Medicine: Structure of Biological Macromolecules and Its Relevance in Combating New Diseases and Bioterrorism", May 29 to June 8, 2008. The papers span the breadth of material presented, which emp- size the practical aspects of modern macromolecular crystallography and its applications to medicine. Topics addressed span from the selection of targets, through to structure determination, interpretation and exploitation. A particular theme that emerges is the dependence of modern structural science on multiple experimental and computational techniques. It is both the development of these techniques and their integration that will take us forward in the future. The NATO ASI directors worked alongside, and offer deep gratitude to Prof. Sir Tom Blundell, Director of the International School of Crystal- graphy, Dr Colin Groom, Dr Neera Borkakoti, Dr John Irwin and Prof. Lodovico Riva di Sanseverino, who were in turn supported by a number of local facilitators. The course was financed by NATO as an Advanced Study Institute. Additional support was given by the European Crystallographic Association, the International Union of Biochemistry and Molecular Biology, the Int- national Union of Crystallography, the University of Bologna, AstraZeneca, Roche, Merck & Co., Boehringer Ingelheim, Bruker Corporation, Douglas Instruments, Informa UK, the Department of Pharmaceutical Chemistry, TTP Lab Tech, University of California at San Francisco. Joel L. Sussman and Paola Spadon
A Century of X-Rays and Radioactivity in Medicine: With Emphasis on Photographic Records of the Early Years celebrates three great discoveries-x-rays (1895), radioactivity (1896), and radium (1898)-and recalls the pioneering achievements that founded the new science of radiology and changed the face of medicine forever. Over 700 historical illustrations with full and informative captions are supported by short introductory essays to illuminate the fascinating radiological past in an easy-to-read style. The focus of this book is on the historically more interesting early years of discovery, invention, diagnosis, therapy, dosimetry, risk, and protection. Interspersed with a variety of radiological anecdotes, the photographic record is complemented by archival accounts of the pioneer scientists and physicians and their early patients. In the chapters on diagnostic techniques, radiotherapy, and nuclear medicine, the author contrasts old methods with newer technologies. He also includes two fascinating chapters on museum and industrial applications of radiography. The book is comprehensively indexed for easy retrieval of the wide variety of people, techniques, apparatus, and examples featured throughout this radiological journey.
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